Alprazolam Major substrate of 3A4
Aspirin Minor substrate of 2C8/9
Carbamazepine Major substrate of 3A4, minor substrate of 2C8/9; strong inducer of
1A2, 2B6, 2C8/9, 2C19, 3A4
Ciprofloxacin hydrochloride Inhibitor of 1A2 and 3A4
Clarithromycin Substrate and inhibitor of 3A4
Diazepam Substrate of 1A2, 2B6, 2C8/9, 2C19, 3A4; weak inhibitor of 2C19
and 3A4
Erythromycin Substrate and inhibitor of 3A4
Ibuprofen Substrate and inhibitor of 2C8/9
Ketoconazole Substrate of 3A4; inhibitor of 1A2, 2C8/9, 2C19, 3A4, 2D6
Midazolam Major substrate of 3A4
Nafcillin Strong inducer of 3A4
Naproxen Minor substrate of 1A2, 2C8/9
Oxycodone/acetaminophen Acetaminophen, substrate of 1A2 and 2E1, weak inhibitor of 3A4
Oxycodone, substrate of 2D6
Phenobarbital Inducer of 3A4, 1A2, 2A6, 2B6, 2C8/9; substrate of 2C8/9, 2C19, 2E1
Phenytoin sodium Major substrate of 2C8/9, 2C19; minor substrate of 3A4; strong
inducer of 2B6, 2C8/9, 2C19, 3A4
SMX/TMP SMX, major substrate of 2C8 and 2C9, minor substrate of 3A4;
inhibitor of 2c8 and 2c9; TMP, substrate of 2C8/9, 3A4; moderate
inhibitor of 2C8/9
Temazepam Minor substrate of 2B6, 2C8/9, 2C19, 3A4
Tramadol Substrate of 2D6, 3A4
Valproate sodium Substrate of 2A6, 2B6, 2C8/9, 2C19, 2E1; inhibitor of 2C8/9, 2C19,
2D6, 3D4; inducer of 2D6